​De Cunzo is a historical anthropologist specializing in the 17th - 19th century cultural histories of the Middle Atlantic region and 20th - 21st century heritage preservation and interpretation of these histories. She has directed public archaeological projects in Delaware in collaboration with the Delaware Historical Society, New Castle Historical Society, New Castle Presbyterian Church, Delaware Division of Historical and Cultural Affairs, Mt. Cuba Center, Delaware Nature Society, and the Old Swedes Foundation. At the University of Delaware, De Cunzo is engaged in the collaborative, interdisciplinary work of the Center for Material Culture Studies, the Winterthur Program in American Material Culture Studies, and the Preservation Studies graduate programs.

De Cunzo's current research explores 17th-century colonialism in the borderlands of the lower Delaware Valley and the African American experience in northern Delaware. Book projects include New Stories from Old Things (co-editor, author) at Delaware Historical Society's Read House and Gardens in New Castle and Encountering 'Others' and the Material World of the Early Colonial Lower Delaware Valley (editor, author). As president of the Society for Historical Archaeology, De Cunzo has worked to globalize the practice of historical archaeology in the United States.